8976 - 9000 of 9146 Results
Title
Year
- Discovery, Synthesis, and Structure–Activity Relationship Development of a Series of N-4-(2,5-Dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): Characterization of a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4) with Oral Efficacy in an Antiparkinsonian Animal Model2011OPENTitle: Discovery, Synthesis, and Structure–Activity Relationship Development of a Series of N-4-(2,5-Dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): Characterization of a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4) with Oral Efficacy in an Antiparkinsonian Animal ModelJournal Name: Journal of Medicinal ChemistryPublisher: American Chemical Society (ACS)Vol: 54Issue #: 21Start Page: 7639End Page: 7647Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1021/jm200956qCitation Count: 61
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OPENTitle: Apathy and Depression: Separate Factors in Parkinson's DiseaseJournal Name: Journal of the International Neuropsychological SocietyPublisher: Cambridge University Press (CUP)Vol: 17Issue #: 6Start Page: 1058End Page: 1066Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1017/s1355617711001068Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3302577Citation Count: 140
- Discovery, Synthesis, and Structure−Activity Relationship Development of a Series of N-(4-Acetamido)phenylpicolinamides as Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4 (mGlu4) with CNS Exposure in Rats2011OPENTitle: Discovery, Synthesis, and Structure−Activity Relationship Development of a Series of N-(4-Acetamido)phenylpicolinamides as Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4 (mGlu4) with CNS Exposure in RatsJournal Name: Journal of Medicinal ChemistryPublisher: American Chemical Society (ACS)Vol: 54Issue #: 4Start Page: 1106End Page: 1110Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1021/jm101271sCitation Count: 48
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OPENTitle: Nicotine up-regulates α4β2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoningJournal Name: Journal of General PhysiologyPublisher: Rockefeller University PressVol: 137Issue #: 1Start Page: 59End Page: 79Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1085/jgp.201010532Best OA location URL: https://rupress.org/jgp/article-pdf/137/1/59/1187438/jgp_201010532.pdfCitation Count: 167
- TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cord2014RESTRICTEDTitle: TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cordJournal Name: Acta NeuropathologicaPublisher: Springer Science and Business Media LLCVol: 128Issue #: 3Start Page: 423End Page: 437Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1007/s00401-014-1299-6Citation Count: 288
- Higher serum cholesterol and decreased Parkinson's disease risk: A statin‐free cohort study2018RESTRICTEDTitle: Higher serum cholesterol and decreased Parkinson's disease risk: A statin‐free cohort studyJournal Name: Movement DisordersPublisher: WileyVol: 33Issue #: 8Start Page: 1298End Page: 1305Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1002/mds.27413Citation Count: 131
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OPENTitle: Cognitive Stress Reduces the Effect of Levodopa on Parkinson's Resting TremorJournal Name: CNS Neuroscience & TherapeuticsPublisher: WileyVol: 23Issue #: 3Start Page: 209End Page: 215Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1111/cns.12670Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cns.12670Citation Count: 108
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OPENTitle: Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after EndocytosisJournal Name: NeuronPublisher: Elsevier BVVol: 65Issue #: 1Start Page: 66End Page: 79Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neuron.2009.12.023Best OA location URL: http://www.cell.com/article/S0896627309010411/pdfCitation Count: 1065
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OPENTitle: Plasticity in Early Alzheimer DiseaseJournal Name: Topics in Geriatric RehabilitationPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 27Issue #: 4Start Page: 257End Page: 267Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1097/tgr.0b013e31821e588eBest OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3419487Citation Count: 44
- Differential contribution of Ih to the integration of excitatory synaptic inputs in substantia nigra pars compacta and ventral tegmental area dopaminergic neurons2015RESTRICTEDTitle: Differential contribution of Ih to the integration of excitatory synaptic inputs in substantia nigra pars compacta and ventral tegmental area dopaminergic neuronsJournal Name: European Journal of NeurosciencePublisher: WileyVol: 42Issue #: 9Start Page: 2699End Page: 2706Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1111/ejn.13066Citation Count: 33
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RESTRICTEDTitle: Transplantable living scaffolds comprised of micro-tissue engineered aligned astrocyte networks to facilitate central nervous system regenerationJournal Name: Acta BiomaterialiaPublisher: Elsevier BVVol: 38Issue #:Start Page: 44End Page: 58Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.actbio.2016.04.021Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/5457669Citation Count: 87
- Independent comparison of CogState computerized testing and a standard cognitive battery with neuroimaging2014RESTRICTEDTitle: Independent comparison of CogState computerized testing and a standard cognitive battery with neuroimagingJournal Name: Alzheimer's & DementiaPublisher: WileyVol: 10Issue #: 6Start Page: 779End Page: 789Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.jalz.2014.09.001Citation Count: 34
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RESTRICTEDTitle: Selective Small Molecule Inhibition of Poly(ADP-Ribose) Glycohydrolase (PARG)Journal Name: ACS Chemical BiologyPublisher: American Chemical Society (ACS)Vol: 7Issue #: 3Start Page: 563End Page: 570Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1021/cb200506tBest OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3306470Citation Count: 54
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OPENTitle: Solution-Phase Parallel Synthesis and SAR of Homopiperazinyl Analogs as Positive Allosteric Modulators of mGlu4Journal Name: ACS Combinatorial SciencePublisher: American Chemical Society (ACS)Vol: 13Issue #: 2Start Page: 159End Page: 165Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1021/co1000508Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3057427Citation Count: 8
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OPENTitle: Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer’s diseaseJournal Name: Acta NeuropathologicaPublisher: Springer Science and Business Media LLCVol: 129Issue #: 4Start Page: 565End Page: 583Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1007/s00401-015-1395-2Best OA location URL: https://link.springer.com/content/pdf/10.1007/s00401-015-1395-2.pdfCitation Count: 56
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OPENTitle: Endpoints and Analyses to Discern Disease-Modifying Drug Effects in Early Parkinson’s DiseaseJournal Name: The AAPS JournalPublisher: Springer Science and Business Media LLCVol: 11Issue #: 3Start Page: 456End Page: 64Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1208/s12248-009-9123-2Best OA location URL: https://link.springer.com/content/pdf/10.1208/s12248-009-9123-2.pdfCitation Count: 68
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OPENTitle: Structural alterations of the intestinal epithelial barrier in Parkinson’s diseaseJournal Name: Acta Neuropathologica CommunicationsPublisher: Springer Science and Business Media LLCVol: 3Issue #: 1Start Page: 12End Page: 12Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s40478-015-0196-0Best OA location URL: https://actaneurocomms.biomedcentral.com/counter/pdf/10.1186/s40478-015-0196-0Citation Count: 294
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OPENTitle: Novel Antioxidants Protect Mitochondria from the Effects of Oligomeric Amyloid Beta and Contribute to the Maintenance of Epigenome FunctionJournal Name: ACS Chemical NeurosciencePublisher: American Chemical Society (ACS)Vol: 6Issue #: 4Start Page: 588End Page: 598Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1021/cn500323qBest OA location URL: http://doi.org/10.1021/cn500323qCitation Count: 11
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OPENTitle: Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanismsJournal Name: Acta NeuropathologicaPublisher: Springer Science and Business Media LLCVol: 121Issue #: 6Start Page: 705End Page: 719Publication Date:Open Access(OA) Status: OPENLicense: cc-by-ncDOI - Digital Object Identifier: 10.1007/s00401-011-0806-2Best OA location URL: https://link.springer.com/content/pdf/10.1007/s00401-011-0806-2.pdfCitation Count: 65
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OPENTitle: Anosognosia increases caregiver burden in mild cognitive impairmentJournal Name: International Journal of Geriatric PsychiatryPublisher: WileyVol: 31Issue #: 7Start Page: 799End Page: 808Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/gps.4394Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/8483618Citation Count: 56
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OPENTitle: Reduced striatal tyrosine hydroxylase in incidental Lewy body diseaseJournal Name: Acta NeuropathologicaPublisher: Springer Science and Business Media LLCVol: 115Issue #: 4Start Page: 445End Page: 451Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s00401-007-0313-7Best OA location URL: http://doi.org/10.1007/s00401-007-0313-7Citation Count: 127
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OPENTitle: Extracellular vesicle sorting of α-Synuclein is regulated by sumoylationJournal Name: Acta NeuropathologicaPublisher: Springer Science and Business Media LLCVol: 129Issue #: 5Start Page: 695End Page: 713Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1007/s00401-015-1408-1Best OA location URL: https://link.springer.com/content/pdf/10.1007/s00401-015-1408-1.pdfCitation Count: 166
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OPENTitle: Measurement of LRRK2 Kinase Activity by Proximity Ligation AssayJournal Name: BIO-PROTOCOLPublisher: Bio-Protocol, LLCVol: 11Issue #: 17Start Page: e4140End Page: e4140Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.21769/bioprotoc.4140Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/8443460Citation Count: 14
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OPENTitle: Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long termJournal Name: Acta NeuropathologicaPublisher: Springer Science and Business Media LLCVol: 135Issue #: 1Start Page: 65End Page: 83Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1007/s00401-017-1792-9Best OA location URL: https://link.springer.com/content/pdf/10.1007%2Fs00401-017-1792-9.pdfCitation Count: 226
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OPENTitle: Development and evaluation of [18F]Flotaza for Aβ plaque imaging in postmortem human Alzheimer’s disease brainJournal Name: Bioorganic & Medicinal Chemistry LettersPublisher: Elsevier BVVol: 46Issue #:Start Page: 128164End Page: 128164Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.bmcl.2021.128164Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/8379902Citation Count: 15