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MJFF Publications

The Michael J. Fox Foundation continually strives to communicate our scientific progress with the research community — through posters and presentations at meetings, in peer-reviewed scientific publications and with white paper reports.

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    Overview of Mood/Psychosis Models

    Mood issues such as depression, anxiety, and apathy are common non-motor symptoms of Parkinson’s disease (PD). Some reports suggest that up to 90% of patients experience at least one of these…
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    Overview of Motor Dysfunction Models

    Parkinson’s disease (PD) is classified as a movement disorder due to the predominant issues in tremor, gait, balance, and bradykinesia. These symptoms are linked to loss of dopamine neurons in the…
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    Research Resources Available Through the Michael J. Fox Foundation

    For the past 23 years, MJFF has supported the Parkinson’s disease (PD) research community by funding research in PD biology, biomarkers, and preclinical through clinical therapeutic developments…
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    Overview of Olfactory Dysfunction Models

    Olfactory dysfunction is a common issue in Parkinson’s disease (PD), affecting 70-95% of patients. Symptoms include impairments in odor detection, identification, and discrimination. Interestingly,…
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    Overview of Cognitive Dysfunction Models

    Cognitive dysfunction is a common issue in Parkinson’s disease (PD). Symptoms include impairments in working memory, learning, attention, cognitive flexibility, and social cognition. Cognitive…
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    MJFF LRRK2 Mouse Motor Phenotyping Study

    MJFF phenotyped the motor function of the various LRRK2 mouse models generated through the Research Tools Program.  Models include WT LRRK2 BAC, G2019S LRRK2 BAC, R1441G LRRK2 BAC, LRRK2 KO,…
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    MJFF Alpha-Synuclein KO and A53T KI Rat Characterization Study

    MJFF performed extensive phenotyping of the aSyn KO and humanized A53T aSyn KI rats that were generated through the MJFF Research Tools Program. Assessments were made at multiple timepoints and…
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Articles authored by Rachel Dolhun, MD, a movement disorder specialist on staff at MJFF, offer a practical review of topics related to Parkinson's disease for practicing clinicians.

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    Alpha-Synuclein: A Therapeutic Target and Potential Biomarker in Parkinson's Disease

    A detailed discussion of our current understanding of alpha-synuclein biology and the ongoing research and development surrounding its role in Parkinson's disease.
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    Diagnosis and Management of Neurodegenerative Atypical Parkinsonism

    A detailed consideration of the neurodegenerative diseases that can cause parkinsonism including dementia with Lewy bodies (DLB), multiple system atrophy (MSA), progressive supranuclear palsy (PSP)…
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    Deep Brain Stimulation and Magnetic Resonance-guided Focused Ultrasound

    A review of innovations in surgical Parkinson's disease treatments, inlcuding deep brain stimulation and magnetic resonance-guided focused ultrasound.
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    Dystonia and Parkinson's Disease

    An exploration of the various manifestations of dystonia in the context of Parkinson's disease.
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    Levodopa 2.0: New Strategies to Even Out the Peaks and Valleys

    A discussion on the latest in new formulations and supplemental therapies of levodopa.
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    Dementia with Lewy Bodies: In the News and in the Clinic

    A practical review of the diagnosis and management of dementia with Lewy bodies.
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Female researcher pipetting in lab.

Breaking Research Updates

Read the latest developments in the field’s understanding and treatment of Parkinson’s disease.

Read Research News
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