The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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GBA Biology and Therapies, 2018Targeting GCase with Novel Pharmacological Chaperones
Study Rationale:
People who have mutations in the GBA gene have a higher chance of developing Parkinson's disease (PD). The GBA gene encodes the glucerebrosidase (GCase) protein, an enzyme located... -
GBA Biology and Therapies, 2018Impact of Genetic Variants in GBA on Parkinson’s Disease
Study Rationale:
Changes to the DNA sequence are risk factors for Parkinson’s disease. While we know where many of these changes occur in our DNA, we still do not know how they cause Parkinson’s... -
GBA Biology and Therapies, 2018Genotypic Influences on Network Progression in Parkinson’s Disease
Study Rationale:
Parkinson’s disease patients with mutations in the glucocerebrosidase (GBA) gene tend to have a more aggressive disease course. GBA pathways may therefore constitute a discrete target... -
GBA Biology and Therapies, 2018GBA Defects Cause C5a-C5aR1-induced Neurodegeneration in Parkinson’s Disease
Study Rationale:
People with GBA-associated Parkinson’s disease (PD) lack enzymes that break down certain fatty molecules (e.g., glucosylceramide), preventing their cells from shedding these waste... -
GBA Biology and Therapies, 2018Live Cell Image-based Screening and Validation of Glucocerebrosidase Activators
Study Rationale:
Changes in the gene GBA that cause malfunction of a protein known as glucocerebrosidase (GCase) are found in about 10 percent of Parkinson’s disease (PD) patients. Even those PD... -
GBA Biology and Therapies, 2018Role of GBA in Mitochondrial Antigen Presentation
Study Rationale:
Parkinson’s disease is caused by the death of dopaminergic neurons in the brain. We propose that the immune system plays a key role in the death of dopaminergic neurons during PD via a...
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