The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Access to Data and Biospecimens, 2017LRRK2 in predicting Parkinson disease risk and progression in LRRK2 mutation carriers
Study Rationale:
The G2019S mutation in the LRRK2 gene is responsible for thousands Parkinson disease (PD) cases. But, not all of the mutation carriers will develop PD. Currently, clinicians...
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Therapeutic Pipeline Program, 2018Disease-modifying Glucocerebrosidase Therapy for Parkinson's Disease
Study Rationale:
Many people with Parkinson's disease (PD) have an abnormal glucocerebrosidase (GBA) enzyme, which causes them to accumulate fatty acids -- chemicals that make up fat -- in the brain... -
Mitochondrial Biomarkers Program, 2018N-formyl Peptides as Novel Biomarkers for Parkinson's Disease
Study Rationale:
Mitochondria -- the powerhouses of the cell -- have their own DNA that contains the instructions to make thirteen proteins. Fragments of these proteins, known as N-formyl peptides... -
Target Advancement Program, 2018Searching for and Targeting Calcium Channels that Control Alpha-synuclein Release
Study Rationale:
Being the primary component of Lewy bodies -- protein clumps that are the pathological hallmark of Parkinson's disease (PD) -- the protein alpha-synuclein plays the central role in PD... -
Research Grant, 2018PAK6 Activity as a Therapeutic Target in LRRK2-associated Parkinson's Disease
Study Rationale:
Mutations (changes) in the gene for the leucine-rich repeat kinase 2 (LRRK2) protein cause inherited Parkinson's disease (PD). Because the activity of LRRK2 is increased in such mutant... -
Target Advancement Program, 2016Studying Monocyte Entry into the Brain in Alpha-synuclein-induced Parkinson's Disease
Study Rationale:
Alpha-synuclein is a sticky protein that clumps in the brains of people with Parkinson's disease (PD). In pre-clinical models, alpha-synuclein clumps attract scores of CCR2-positive...
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Our funding programs support basic, translational and clinical research from academia and industry.