The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2019Targeting LRRK2 in Models of Gastrointestinal Inflammation
Study Rationale:
We seek to investigate the extent to which gut inflammation triggers brain inflammation and Parkinson’s-like pathology and the role of LRRK2 and Tumor Necrosis Factor (TNF)-dependent... -
Research Grant, 2019Alpha-Synuclein PET Imaging Tracer Development
Study Rationale:
Alpha-synuclein is a protein that aggregates in several brain diseases, including Parkinson’s, dementia with Lewy bodies and multiple system atrophy. There is no established method... -
Target Advancement Program, 2019Analysis and Amplification of Pathological Alpha-synuclein from Brain Tissue
Study Rationale:
Parkinson’s disease is characterized by the misfolding and accumulation of the alpha-synuclein protein in the brain. Therefore, alpha-synuclein-based disease... -
Research Grant, 2019Astrocyte Activation as a Novel Marker of Disease Progression in Parkinson’s Disease: A PET Imaging Study
Study Rationale:
Brain inflammation, regulated by cells called microglia and astrocytes, has been shown to play a role in the initiation and progression of Parkinson’s disease. However, the role of... -
Target Advancement Program, 2019Connexins as a New Therapeutic Target to Impede Spreading of Alpha-synuclein Pathology
Study Rationale:
Direct cellular connectivity has recently been implicated in the transfer of alpha-synuclein pathology associated with Parkinson’s disease. The gap junction proteins known as... -
Target Advancement Program, 2020Determining the Ligase and DUB Landscape of Mitochondrial and Alpha-synuclein Turnover
Study Rationale:
Research suggests that accumulation of faulty mitochondria (the “powerhouse” of the cell) or mutated forms of the protein alpha-synuclein in the brain contribute to the...
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Our funding programs support basic, translational and clinical research from academia and industry.