The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2020Investigating the Role of LRRK2 in Tau Pathogenesis
Study Rationale:
While most cases of Parkinson’s disease have no known genetic cause, a subset of Parkinson’s is caused by mutations in the leucine-rich repeat kinase 2 (LRRK2) gene. It is believed... -
Research Grant Supplement, 2020Measuring LRRK2-Mediated Rab Protein in Parkinson’s Disease
Study Rationale:
The discovery of LRRK2 (Leucine rich repeat kinase 2) recently as a gene that causes Parkinson’s disease has provided considerable insights into the development of both familial and... -
Research Grant, 2020Cytokine Production by Adaptive Immune Cells in Parkinson’s Disease: Response to Diverse Biological Stimuli
Study Rationale:
Many studies indicate a role for the adaptive immune system in Parkinson’s disease. Our study will produce proteins called cytokines that play a role in the immune response to... -
Biosample Use Program, 2020Relationship of Plasma Vitamin B12 and Homocysteine Levels with Outcomes in SURE-PD and STEADY-PD Trials
Study Rationale:
Vitamin B12 levels are lower in people with Parkinson’s disease. Our prior investigation showed that lower B12 levels were associated with more rapid worsening of gait and stability... -
Biosample Use Program, 2020Single-molecule Detection of Oligomeric Synuclein in Body Fluids
Study Rationale:
Clumps, or aggregates, of the protein alpha-synuclein have been detected in spinal fluid of people with Parkinson’s disease, where its concentration shows potential to be a biomarker... -
Research Grant, 2020RT-QuIC Assay for Alpha-synuclein in Incidental Lewy Body Disease
Study Rationale:
In Parkinson's, the alpha-synuclein protein misfolds and aggregates into clumps, called Lewy bodies. When Lewy bodies are found in people without Parkinson’s, it can be diagnosed as...
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Our funding programs support basic, translational and clinical research from academia and industry.