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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Fall 2021 RFP: Outcome Measures, 2022
    Common Mitochondrial DNA Deletions as a Peripheral Marker of Parkinson’s Disease

    Study Rationale: Mitochondria are small capsules inside cells that generate energy. There are lots of mitochondria in brain cells because the brain uses a lot of energy. Researchers have found that...

  • Diversity, Equity and Inclusivity in Parkinson's research, 2022
    Parkinson’s Disease in Southern Africa

    Study Rationale: Most studies on Parkinson’s disease (PD) are focused on patients in Europe and North America. It is crucial to investigate patterns and the causes PD in other parts of the world. It...

  • Fall 2021 RFP: Outcome Measures, 2022
    LRRK2 Kinase Activity and Global Proteomic Biomarkers in the Gut of Patients with Parkinson’s and/or Inflammatory Bowl Disease

    Study Rationale: Accumulative evidence suggests a strong connection between the brain and the gut, with chronic intestinal inflammation being linked to an increased risk of Parkinson’s disease (PD)...

  • 2022: Accelerated Therapeutics Program, 2022
    Preclinical and Early Clinical Development of NPT1220-478 for the Treatment of Parkinson's Disease

    Study Rationale: Parkinson’s disease is a progressive neurodegenerative disorder; meaning that from its inception, neurons are continuously dying with resulting worsening of neurologic symptoms. Two...

  • Fall 2021 RFA: Promoting Diversity, Equity and Inclusion in Parkinson’s Disease Research, 2022
    Preventing Fractures in Parkinson’s Disease by Identifying Barriers to Care and Social Determinants of Health

    Study Rationale: Compared with the general population, people with Parkinson’s disease (PD) are more likely to fall and break a bone as a result of disease-related motor issues, such as difficulty...

  • Alpha-synuclein Seed Amplification Assay Program, 2022
    Maximizing the Sensitivity of Seed Amplification Assays Used to Detect Alpha-synuclein Aggregates

    Study Rationale: One characteristic of Parkinson’s disease (PD) is the aggregation of proteins such as alpha-synuclein in the brain. To diagnose PD, it is important to be able to detect such...

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