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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2014
    Role of Striatal Cholinergic Interneurons in Parkinson’s Disease Dyskinesia

    Study Rationale:                   
    In pre-clinical models, we identified an important role of cholinergic interneurons — which release the neurotransmitter acetylcholine — from part of the brain...

  • Research Grant, 2014
    Gene Expression Changes in Striatal Cholinergic Interneurons Associated with Levodopa-induced Dyskinesia

    Study Rationale:                   
    In pre-clinical models, we identified an important role of cholinergic interneurons — which release the neurotransmitter acetylcholine — from part of the brain...

  • Rapid Response Innovation Awards, 2014
    Potential of Cell-permeable Parkin Proteins as a Treatment for Parkinson’s Disease

    Objective/Rationale:
    Parkin is an enzyme that protects cells, including neurons, from damage. Mutations in parkin can lead to loss of neurons and contribute to Parkinson’s disease (PD). We plan to...

  • Research Grant, 2014
    Selective mGluR3 Positive Allosteric Modulators as Neuroprotective Agents for Parkinson's Disease

    Objective/Rationale:            
    mGluR3 is a protein and target for neuroprotection. We have recently demonstrated that selective mGluR3 positive allosteric modulators (PAMs) mimic neuroprotective...

  • Parkin Therapeutic Development, 2014
    Identification of Small Molecules that Stabilize Parkin in an Active Conformation

    Objective/Rationale:
    Parkin is a protein linked to hereditary, young-onset Parkinson’s disease (PD) through a series of genetic mutations. Its formal role in PD is not fully understood, but its...

  • Research Grant, 2014
    Parkin-mediated Mitigation of Neurodegeneration Induced by Overexpression of Alpha-synuclein Using AAV Vectors

    Objective/Rationale:
    Mutations in the gene for the protein parkin gene can cause Parkinson’s disease (PD), and parkin is involved in the breakdown of damaged proteins. This makes parkin an important...

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