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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Biosample and Tissue Resource, 2013
    Discovery of Changes in N-linked Glycans Associated with Parkinson’s Disease

    Objective/Rationale:             
    The objective of this study is to explore the role of glycans (sugars attached to proteins) in the development and progression of Parkinson’s disease (PD). Glycans...

  • LRRK2 Challenge, 2013
    Investigation of LRRK2 as a Regulator of Microglial Cell Function

    Objective/Rationale:             
    Mutations of the LRRK2 gene are associated with Parkinson’s disease (PD), but very little is known about how or where the LRRK2 kinase normally functions in the brain...

  • Cognition Biomarkers, 2013
    Identification and Validation of Cerebrospinal Fluid Markers Related to Altered Amyloid-beta Processing in the Prediction of Dementia Associated with Parkinson’s Disease

    Objective/Rationale:             
    Patients with Parkinson’s disease (PD) are at increased risk to develop dementia compared with the general population. However, not all patients experience this...

  • Research Grant, 2013
    Comparative Characterization of Alpha-synuclein Species and Identification of Antibodies that Detect and Capture Alpha-synuclein

    Objective/Rationale:             
    The identification and validation of biomarkers of Parkinson’s disease (PD)  is crucial for diagnosing the disease early, monitoring disease progression, designing...

  • Cognition Biomarkers, 2013
    Validation of Computer-based Saccade Measures as a Biomarker for Neurocognitive Changes in Parkinson's Disease

    Objective/Rationale:
    Saccades are fast eye movements that shift visual focus for tasks like reading, visual searching and coordinating safe movement. Research has shown that the speed, accuracy and...

  • Cognition Biomarkers, 2013
    Assessment of Plasma Glucosylceramides and Ceramides as Biomarkers of Cognitive Impairment in Parkinson's Disease

    Objective/Rationale:
    Metabolism of the lipids glucosylceramide and ceramide is altered in Parkinson’s disease (PD). GBA mutations in this pathway, causing a build-up of glucosylceramide, increase the...

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