Study Rationale:
Voice and communication deficits are common in Parkinson’s disease. They occur early in the disease process, are progressive in nature, and significantly impact quality of life. However, despite their impact, vocalization deficits are rarely the focus of preclinical studies and are unimproved by current medical treatments. The goal of this project is to use a preclinical model to better understand the specific regions, underlying mechanisms, and aspects of vocal training that influence Parkinson’s specific voice and communication deficits.
Hypothesis:
We hypothesize that pathology in the cranial sensorimotor system specifically results in early vocalization deficits and represents an early disease marker. We also hypothesize that vocal training will specifically target pathology in the cranial sensorimotor system and should serve as an early therapeutic option in Parkinson’s disease.
Impact on Diagnosis/Treatment of Parkinson’s disease:
Results will provide a critical and necessary foundational understanding of the underlying mechanisms that lead to early voice and communication deficits in Parkinson’s disease.
Next Steps for Development:
Results of this proposal will aid in the development of novel approaches to diagnose and treat voice and communication deficits related to Parkinson’s disease.