The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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LRRK2 Role in Idiopathic Parkinson's Disease, 2014Age-related Alterations in LRRK2 Expression and Function in Immune Cells and Risk for Idiopathic Parkinson's Disease
Objective/Rationale:
The LRRK2 protein is highly expressed in immune cells, but its function is unknown and may change as the immune system changes with aging and environmental exposures, the largest... -
LRRK2 Role in Idiopathic Parkinson's Disease, 2014Non-dopaminergic Systems in the Evolution of LRRK2 Parkinsonism
Objective/Rationale:
Researchers have previously demonstrated that the pattern and evolution of progressive changes in the dopamine system in Parkinson’s disease (PD) associated with LRRK2 mutations... -
LRRK2 Role in Idiopathic Parkinson's Disease, 2014Activation of Microglial LRRK2 by Alpha-synuclein: LRRK2 Pathogenesis in Idiopathic PD
Objective/Rationale:
Alpha-synuclein is a protein that plays an important role in all forms of Parkinson’s disease (PD). Recent data demonstrate that brain cells can secrete alpha-synuclein and that... -
LRRK2 Role in Idiopathic Parkinson's Disease, 2014Deciphering the Genetic Architecture of the LRRK2 Gene in the Indian Population
Objective/Rationale:
Genetic variability in the LRRK2 gene is recognized as one of the most common cause of Parkinson’s disease (PD) mainly in the Caucasian, African-Arab, Ashkenazi Jewish and East... -
LRRK2 Role in Idiopathic Parkinson's Disease, 2014Assessing the Role of LRRK2 in Sporadic Parkinson’s Disease Using iPSC-derived Dopaminergic Neurons
Objective/Rationale:
Mutations in the LRRK2 gene are the greatest known contributors to genetic forms of Parkinson’s disease (PD). This project will investigate whether LRRK2 function also plays a role... -
Research Grant, 2014LRRK2 Expression in Postmortem Brain
Objective/Rationale:
Mutations in LRRK2 are a major genetic cause of Parkinson’s disease. This study aims to determine what happens to the amount of LRRK2 protein in the brains of people with Parkinson...
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Our funding programs support basic, translational and clinical research from academia and industry.