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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • LRRK2 Challenge, 2013
    LRRK2 and Vitamin D3 Metabolism

    Objective/Rationale:             
    The LRRK2 kinase enzyme is mutated in some patients with Parkinson’s disease (PD). Coincidentally, the kinase is widely expressed in most organs of the body. We...

  • Target Validation, 2013
    Significance of Miro in the Pathogenesis of Parkinson's Disease

    Objective/Rationale:             
    Miro is a protein on the outer membrane of mitochondria. Miro anchors kinesin motor proteins to mitochondria; the kinesins transport mitochondria to where they need...

  • MJFF Research Grant, 2013
    Characterization of LRRK2 Inhibitors for Advanced Drug-like Properties

    Objective/Rationale:             
    Zenobia Therapeutics has identified a unique series of highly specific and potent LRRK2 inhibitors with central nervous system drug-like chemical properties using the...

  • Rapid Response Innovation Awards, 2013
    Structure-based Design of Pharmacological Activators of Parkin

    Objective/Rationale:             
    Mutations in the Parkin gene are responsible for a familial form of Parkinson’s disease (PD). The gene encodes a protein whose activity has been shown to protect...

  • Research Grant, 2013
    LRRK2 Role on Auto-antibody Production by Human B Cells

    Objective/Rationale:             
    B lymphocytes are cells of the immune system that have a dual function: they produce antibodies to fight disease-causing agents, and they participate in the...

  • RRIA (Rapid Response Innovation Awards), 2013
    Role of GSK-3beta in Parkinson’s Disease

    The protein GSK-3beta has not previously been linked to Parkinson’s disease (PD). Recently, we have studied pre-clinical models with high levels of GSK-3beta throughout the brain. At a younger age [up...

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