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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2017
    Searching for the Cause of Parkinson’s Disease in People with GBA Mutations

    Study Rationale:
    The GBA gene is responsible for the production of beta-glucocerebrosidase, an enzyme that breaks down fats. Scientists are starting to recognize changes, or mutations, in the GBA gene...

  • Computational Science, 2017
    Using "Big Data" Methods to Better Plan Clinical Trials and Predict Outcomes of Parkinson's Disease

    Study Rationale:
    Parkinson’s disease (PD) progresses differently in every case, which makes reliable prediction of future outcomes challenging. Looking for better ways to predict disease progression...

  • LRRK2 Therapeutic and Safety Initiative, 2017
    Using Organs-on-Chips to Test the Safety of New Drugs for Parkinson's Disease

    Study Rationale:
    Organs-on-Chips is a technology that recreates human biology in a microscopic device. In simple terms, the device comprises cells from a human organ, such as the lungs, attached to a...

  • LRRK2 Therapeutic and Safety Initiative, 2017
    Genetic and Clinical Basis for Inflammatory Bowel Disease and Parkinson's Disease Comorbidity

    Study Rationale:
    Recent studies have shown that mutations in the LRRK2 gene, known to increase the risk of Parkinson’s disease (PD), are also associated with inflammatory bowel disease (IBD), a...

  • LRRK2 Biology Consortium, 2017
    LRRK2 Activity and Dyskinesia

    Promising Outcomes of Original Grant:
    Leucine-rich repeat kinase 2 (LRRK2) is the greatest known genetic contributor to Parkinson's disease (PD). We previously studied the role of LRRK2 in the...

  • Computational Science, 2017
    International Study of Parkinson's-related Changes in Brain Pathways Using Imaging Technique

    Study Rationale:
    Because Parkinson's disease (PD) affects people around the world regardless of their ethnicity or place of residence, research to find a cure for Parkinson's is truly an international...

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