The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2017Study of a Molecule to Prevent Alpha-Synuclein Clumping and Treat Parkinson's Disease
Promising Outcomes of Original Grant:
Alpha-synuclein is a sticky protein that clumps in the brains of people with Parkinson's disease (PD). In our first project funded by The Michael J. Fox Foundation... -
LRRK2 Therapeutic and Safety Initiative, 2017Efficacy and Safety of Chronic Treatment with LRRK2 Inhibitors
Study Rationale:
LRRK2 inhibitors are among the most promising in the current generation of potential novel treatments for Parkinson's disease (PD). In pre-clinical models, long-term treatment with... -
Research Grant, 2017Studying the Parkin Protein in New Pre-Clinical Models
Promising Outcomes of Original Grant:
Mitophagy is a cellular process during which damaged mitochondria, or energy generators, are broken down. Mitophagy has been suspected to malfunction in Parkinson... -
Research Grant, 2016Combining Mass Spectrometry with Genetic and Pharmacological Approaches to Discover and Validate LRRK2 Substrates
Study Rationale:
The kinase (protein regulator) LRRK2 is thought to play an important role in both familial (inherited) and sporadic (no known cause) Parkinson's disease (PD). Unfortunately, a lack of... -
Target Advancement Program, 2016Targeting RER1 in Models of Parkinson's Disease
Study Rationale:
Abnormal build-up of the protein alpha-synuclein in Parkinson's disease (PD) has been linked to cell stress and death. These deficits can be rescued by expressing certain proteins... -
Target Advancement Program, 2016Alpha-synuclein Toxicity in LRRK2 Pre-clinical Models and Rescue by LRRK2 Silencing
Study Rationale:
Genetic mutations that alter the function of the LRRK2 protein increase the risk of developing a form of Parkinson's disease (PD). Age and other environmental factors combine with...
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Our funding programs support basic, translational and clinical research from academia and industry.