The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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LRRK2 Biology Consortium, 2017Kinase Activity-mediated Changes in LRRK2-Parkinson's and Sporadic Parkinson's Cells and Rab Protein Function
Promising Outcomes of Original Grant:
Our previous studies have demonstrated deficits in cohesion, positioning, and polarity (important characteristics of cells that help regulate function) in... -
Research Grant, 2017Inflammation in Parkinson's Disease
Study Rationale:
The contribution of inflammation to Parkinson's disease (PD) is increasingly being recognized. However, the stage of the disease in which inflammation is prevalent and/or important...
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Research Grant, 2016Study of Alpha-synuclein in the Dorsal Neostriatum
Promising Outcomes of Original Grant:
In February 2013, Luk et al. published in Science that administration of synthetic alpha-synuclein into pre-formed fibrils in pre-clinical models was sufficient to... -
LRRK2 Biology Consortium, 2017Development of Nanobodies as Novel Tools to Characterize LRRK2 as a Potential Drug Target for Parkinson's Disease
Study Rationale:
Several genes play a crucial role in Parkinson's disease (PD). The most common genetic cause of PD is mutations in the gene encoding LRRK2, a very large and complex protein with... -
Research Grant, 2017Gene Therapy to Restore Protein Imbalance in Parkinson's Disease
Study Rationale:
Parkinson's disease (PD) is characterized by impairment of motor control as a result from extensive neuron death. The primary mechanism responsible for the progressive neuronal loss in... -
Therapeutic Pipeline Program, 2016Effect of HDAC Inhibition in Models of Parkinson's Disease
Study Rationale:
Numerous publications have linked the family of epigenetic enzymes known as HDACs (histone deactylases) to the underlying pathology of Parkinson's. This study will test the efficacy of...
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Our funding programs support basic, translational and clinical research from academia and industry.