The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
-
Research Grant, 2017Development of Analytic Tests to Use as Nilotinib Companion Diagnostics in Parkinson's Disease
Study Rationale:
Evidence suggests that increased activity of the c-abl protein in the brain may contribute to the development and progression of Parkinson's disease (PD). Nilotinib, a drug that... -
Research Grant, 2017White Blood Cell and Urine Collection in LRRK2 and GBA Mutation Carriers
Study Rationale:
Mutations in the LRRK2 and GBA genes increase the risk for Parkinson's disease (PD). The mechanism by which these mutations increase PD risk is unknown. One potential explanation may...
-
Therapeutic Pipeline Program, 2017Small-Molecule Pharmacological Chaperones Reverse Alpha-synuclein-impaired Debris Removal
Study Rationale:
The goal of this project is to find therapeutic drugs for Parkinson's disease (PD) that target alpha-synuclein, a key player in PD. We propose that the negative impact of alpha...
-
LRRK2 Biology Consortium, 2017Characterization of Leukocytes as Biomarkers for LRRK2 and Autophagy in Parkinson's Disease
Study Rationale:
To avoid accumulation of products that may cause toxicity, neurons rely on a series of highly efficient mechanisms of quality control. It has been proposed that, in those with...
-
Target Advancement Program, 2017Neuroprotective Effects of Endosulfine-alpha in Parkinson's Disease
Study Rationale:
Evidence suggests that alpha-synuclein can cause neuron death in Parkinson's disease (PD) by forming clusters (or aggregates) on the surface of small structures inside the cell called... -
Target Advancement Program, 2017Validation of USP30 as a Therapeutic Target for Parkinson's Disease Modification
Study Rationale:
Mitochondria provide energy for neurons to function and survive. Evidence suggests that individuals with Parkinson's disease (PD) have poorly functioning mitochondria, such that the...
Apply for a Grant
Our funding programs support basic, translational and clinical research from academia and industry.