The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2017Promoting Mitochondrial Transport in Dopaminergic Neurons
Study Rationale:
Healthy mitochondria (powerhouses of the cell) are crucial to the survival of neurons, and poorly-functioning mitochondria are implicated in the neurodegeneration associated with... -
Target Advancement Program, 2017Preventing Misfolded Alpha-synuclein Accumulation
Study Rationale:
The pathological hallmark of Parkinson's disease (PD) is the widespread accumulation of cellular deposits (Lewy Bodies) comprised of clumps of a misfolded protein called alpha... -
Improved Biomarkers and Clinical Outcome Measures, 2017Regulation of the SNCA Gene in Parkinson's Disease
Study Rationale:
DNA methylation is a regulatory mechanism that can turn genes on or off within the cells in our body. In Parkinson's disease (PD), methylation near SNCA (a gene linked to PD) is lower... -
Research Grant, 2017Imaging Agents for Tauopathies and Alpha-Synuclein
Study Rationale:
Assessing the accumulation of tau (protein associated with dementia) and alpha-synuclein (sticky protein associated with Parkinson's) in the living human brain is crucial to better... -
Research Grant, 2017The RESISTA-PD trial - The Effects of Resistant Starch on Bowel Habits, Short Chain Fatty Acids and Gut Microbiota in Parkinson Disease
Study Rationale:
Individuals with Parkinson's disease (PD) frequently suffer from constipation; those with PD also have altered bacterial composition in the gut. The RESISTA-PD trial investigates... -
LRRK2 Biology Consortium, 2017From Structure to Function: Targeting LRRK2-mediated Parkinson's Disease
Study Rationale:
Parkinson's disease (PD) mutations in the LRRK2 protein have been linked to decreased GTPase (enzyme that binds to G proteins) activity and increased kinase (enzyme that modifies a...
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Our funding programs support basic, translational and clinical research from academia and industry.