The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutic Pipeline Program, 2016KH176 as a Novel Disease-modifying Therapeutic for Parkinson’s Disease
Study Rationale:
Mitochondrial dysfunction has a prominent role in the process of Parkinson’s disease (PD). Mutations in at least seven genes are known to underlie PD, most of them encode proteins that... -
Therapeutic Pipeline Program, 2016Long-term Cell Restorative Treatment for Parkinson’s Disease
Study Rationale:
Cell replacement therapies for Parkinson’s disease (PD) propose to replace the lost dopaminergic neurons in the brain. Transplanted fetal dopamine neurons have... -
Therapeutic Pipeline Program, 2016USP13 Regulation of Parkin Stability
Study Rationale:
Our data show that the enzyme USP13 is dramatically increased (two-fold) in sporadic Parkinson’s brains, and cell culture studies suggest that USP13 de-ubiquitinates... -
Research Grant, 2016Production of Helper Dependent Adenovirus Type 5 LRRK2 Expression Vectors
Study Rationale:
The LRRK2 gene has been implicated in Parkinson’s disease, but is too large to be expressed in viral vectors, a tool to modify cells. In order to study LRRK2... -
Target Advancement Program, 2016Biochemical Analysis and Structural Determination of LRRK2 with Kinase Inhibitors
Study Rationale:
Although pharmacological and surgical treatments are available to manage the symptoms of Parkinson’s disease (PD), none yet can slow down or stop the course of the... -
Improved Biomarkers and Clinical Outcome Measures, 2016Developing a Molecular Imaging Tool That Binds to Alpha-Synuclein and Inhibits Its Formation
Study Rationale:
Amyloid fibrils play a key role in Parkinson's disease (PD). Studying their formation from self‐assembled aggregates (protein clumps) would help aid the development of a valuable...
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Our funding programs support basic, translational and clinical research from academia and industry.