The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Target Advancement Program, 2016High-throughput LRRK2 Ubiquitination Assay
Study Rationale:
The LRRK2 protein is regulated by modifications called phosphorylation, which occurs at several specific sites on the protein (Serines910, 935, 955, 973) and can alter the biology of... -
Biomarkers Across Neurodegenerative Diseases, 2016Network Models of Neurodegeneration (NetMON)
Study Rationale:
The global aging population has placed neurodegenerative diseases, such as Parkinson’s and Alzheimer’s, among the biggest public health challenges of 21st century healthcare. It is...
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Research Grant, 2016Impact of LRRK2 Kinase Activity on Synaptic Vesicle Trafficking
Promising Outcomes of Original Grant:
Our previous work provided evidence that LRRK2 plays a crucial role in neurons by affecting the trafficking (movement across the cell) of synaptic vesicles... -
Research Grant, 2016LRRK2 Safety Initiative
Study Rationale:
Previous pre-clinical work with Genentech, Inc. has demonstrated that LRRK2 kinase inhibitors may induce abnormal findings in the lungs. This study will determine if this result is due... -
Research Grant, 2016SudoScan as a Biomarker of Parkinson's Disease
Study Rationale:
Currently, there is no single test that can be used to confirm a diagnosis of Parkinson's disease (PD) or a biomarker that can track its progression. People with PD have many... -
Target Advancement Program, 2016Targeting the Mitochondrial Unfolded Protein Response in Alpha-synuclein-induced Parkinson's Disease
Study Rationale:
The mitochondrial (powerhouse of the cell) unfolded protein response (mtUPR) is the first defense mechanism for maintaining proper quality of proteins within the mitochondria. Defects...
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Our funding programs support basic, translational and clinical research from academia and industry.