The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant Supplement, 2015Modulation of MicroRNA Activities in Parkinson's Disease
Objective/Rationale:
Previous data support that small non-coding gene regulatory RNAs, known as microRNAs, are dysregulated in Parkinson’s disease (PD). However, the disease-relevance of these changes... -
Improved Biomarkers and Clinical Outcome Measures, 2015Method to Quantify Parkinsonian Motor Signs for Interventional Drug Trials
Study Rationale:
Current methods to evaluate motor impairments in Parkinson’s disease rely on subjective examinations. Our team seeks to develop an objective assessment of motor... -
Research Grant, 2015Parallel Reaction Monitoring within the Parkin Ubiquitin Ligase System
Study Rationale:
Recent studies have revealed a role for PINK1 and PARKIN, two genes mutated in early onset Parkinson’s disease, function to promote a cellular process called ubiquitylation of... -
Improved Biomarkers and Clinical Outcome Measures, 2015Developing Progression Markers of Parkinson’s Disease with Multimodal Structural MRI of Substantia Nigra and Locus Coeruleus
Study Rationale:
Substantia nigra pars compacta (SNpc) and locus coeruleus (LC) are key brain areas involved in Parkinson’s disease. The loss of important chemicals (dopamine and norepinephrine) made... -
Research Grant Supplement, 2015Identification of the Parkin-binding Domain for SLP-2 as a Potential Therapeutic Target Supplement
Promising Outcomes of Original Grant:
The objective of our Rapid Response Innovation Awards-supported project was to identify the parkin domain that interacts with Stomatin-like protein 2 (SLP-2), a... -
Research Grant, 2015Nuclear Magnetic Resonance Analysis to Support Development of Alpha-Synuclein Imaging Agents
Study Rationale:
The Michael J. Fox Foundation Imaging Consortium has identified several promising compounds that bind specifically to alpha-synuclein fibrils, the clumps of protein that accumulate in...
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Our funding programs support basic, translational and clinical research from academia and industry.