The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2014Evaluation of mGlu4 Positive Allosteric Modulators in Models of Parkinson’s Disease
Study Rationale:
Levodopa and other available treatments for Parkinson’s disease (PD) are initially effective but have unpredictable therapeutic effects and induce serious adverse... -
Therapeutic Pipeline Program, 2014Liver X Receptor Agonists as Novel Therapeutics for Parkinson’s Disease
Study Rationale:
Inflammation is an early and characteristic feature of Parkinson’s disease. Recent studies connect a protein called the liver X receptor (LXR) to inflammation in key... -
Cognition Biomarkers, 2014miRNA Markers of Cognition
Objective/Rationale:
In previous MJFF-funded research, these researchers identified four promising microRNAs (which regulate gene expression) associated with cognitive status. They profiled the miRNAs... -
Parkin Biology, 2014Role of Parkin in Innate Immunity
Objective/Rationale:
The protein Parkin contributes to the elimination of damaged mitochondria by a process called mitophagy. Prior research has shown that silencing Parkin gene affects innate immunity... -
Rapid Response Innovation Awards, 2014The Microbiome in Parkinson's Disease: Role as a Potential Biomarker and Relation to Disease Progression
Promising Outcomes of Original Grant:
In their previous study these researchers investigated whether the abundance of different microbes in the gut differs between Parkinson’s disease (PD) patients and... -
Rapid Response Innovation Awards, 2014Parc (a Parkin-related E3 Ligase): Functions in Neuronal Survival and Parkinson’s Disease
Objective/Rationale:
Parkinson’s disease (PD) is frequently associated with mutations in the gene that encodes Parkin, a protein that detects and degrades dysfunctional mitochondria. While removing...
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Our funding programs support basic, translational and clinical research from academia and industry.