The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Outcome Measures, 2021Development of a Method for Assessing the Effectiveness of Alpha-synuclein Immunotherapy
Study Rationale: Parkinson’s disease (PD) is characterized by the buildup of misfolded forms of alpha-synuclein. A vaccine designed to target this abnormal protein has demonstrated safety...
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Therapeutic Pipeline Program, 2021Development of an Anti-inflammatory Drug for the Treatment of Parkinson’s Disease
Study Rationale: Persistent activation of the immune cells that reside in the brain leads to a state of chronic inflammation that contributes to the degeneration of neurons in Parkinson’s disease (PD)...
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Research Grant, 2021Preclinical Testing of a Novel Tracer for Imaging Alpha-synuclein Aggregates
Study Rationale: In Parkinson's disease (PD), the protein alpha-synuclein is structurally altered such that clumps of alpha-synuclein accumulate in the brain. These aggregates impair the function of...
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Target Advancement Program, 2021Enhancing Treatment Efficacy by Eliminating L-dopa Metabolizing Gut Bacteria
Study Rationale: Levodopa (L-dopa) is the primary medication used to treat Parkinson’s disease (PD). For L-dopa to exert its effect, it must enter the brain and be converted to the chemical dopamine...
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Research Grant, 2021Development of Selective PET Imaging Agents for Alpha-synuclein and Tau
Study Rationale: The ability to detect and monitor the accumulation of tau and alpha-synuclein aggregates in the brain is crucial to better understanding the pathophysiology of Progressive...
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Outcome Measures, 2021Assessing Parkinson’s at Home: Contactless Monitoring of Sleep, Motor Symptom Progression and Medication Response
Study Rationale:
The ability to accurately monitor Parkinson’s disease (PD) progression and medication response at home can significantly benefit disease management and drug development. In the past...
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Our funding programs support basic, translational and clinical research from academia and industry.