The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
-
Alpha-Synuclein Biology, 2018Using Powerful Metabolomic Methods to Identify Blood-based Biomarkers of Early-Stage Parkinson's Disease
Study Rationale:
Metabolomics is an approach to studying molecules that are products of metabolism. Using metabolomics, we identified a unique feature -- metabolic fingerprint -- in the blood of pre... -
Research Grant, 2018A Global Database of People with Inherited Parkinson's Disease
Study Rationale:
Changes (mutations) in genes PRKN, PINK1, DJ1, SNCA, LRRK2 and VPS35 can cause inherited Parkinson's disease (PD). Also, mutations in the GBA gene are associated with an increased... -
Access to Data and Biospecimens, 2018Studying Methylation in the PPMI Cohort to Develop New Biomarkers
Study Rationale:
Because Parkinson's disease (PD) is a complex disease, it is difficult to accurately diagnose and treat. Biomarkers -- disease indicators that are critical missing links in the search... -
Research Grant, 2018Allosteric Targeting of LRRK2 Using Stapled Peptides
Study Rationale:
Mutations in the LRRK2 gene -- which alter enzymatic activity in the LRRK2 protein -- are associated with increased risk of Parkinson's disease. The protein is known to aggregate into... -
Target Advancement Program, 2018Role of 5-alpha Reductase 1 in the Therapy of Neurodegeneration and Levodopa-induced Dyskinesias
Study Rationale:
The two main types of the enzyme 5α-reductase (5αR) play a key role in the production of steroids in the brain and other organs. In pre-clinical testing, we found that inhibitors of... -
Access to Data & Biospecimens, 2018Rapid and Ultra-sensitive Quantitation of Disease-associated and Synuclein Seeds in Brain and Cerebrospinal Fluid by Syn RT-QuIC
Study Rationale:
The diagnosis and treatment of Parkinson’s disease (PD) would be aided by the availability of direct and highly sensitive tests for the abnormal clusters of the...
Apply for a Grant
Our funding programs support basic, translational and clinical research from academia and industry.