The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2018The Role of LRRK2 in Immune Response and Neurodegeneration Caused by Mitochondrial Dysfunction
Study Rationale:
Although mutations (changes) in the LRRK2 gene are more common than changes in other disease-linked genes in people with Parkinson's disease (PD), it remains unclear how the LRRK2 mut... -
Alpha-Synuclein Biology and Therapies, 2018Studying the Function of Modified Alpha-synuclein in Health and Disease
Study Rationale:
The exact cause of brain cell death in people with Parkinson's disease (PD) is not fully understood. Studies have revealed clumps of protein alpha-synuclein in brain cells. Modified... -
Research Grant, 2018Gait as a Measure of Parkinson's Disease
Study Rationale:
Gait impairment -- difficulty walking -- is arguably among the most disabling symptoms of Parkinson's disease (PD), as safe walking is critical for maintaining independence and... -
Research Grant, 2018Tracing Hallmarks of Parkinson's Disease in the Brain with a New Compound
Study Rationale:
Parkinson's disease (PD) is characterized by the presence of protein alpha-synuclein clumps in the brain. PD shares common features with other neurodegenerative diseases and because an... -
LRRK2 Biology Consortium, 2018Developing Cell-Based Tools for the Evaluation of LRRK2 Inhibitors
Promising Outcomes of Original Grant:
Mutations in the LRRK2 gene are a leading genetic cause of Parkinson's disease (PD) and cause dysfunction in the LRRK2 protein. We have previously demonstrated... -
Research Grant, 2018Developing a Reliable Clinical Test for pS129 Alpha-synuclein
Study Rationale:
Alpha-synuclein is a sticky protein that clumps in the brains of people with Parkinson's disease (PD). An abnormal form of the protein, called pS129 alpha-synuclein, can serve as an...
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Our funding programs support basic, translational and clinical research from academia and industry.