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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2018
    Studying Changes in Glucocerebrosidase Activity in People with Parkinson's Disease

    Study Rationale:
    A dysfunction of the glucocerebrosidase (GCase) protein increases the risk of Parkinson's disease (PD). Blood cells called monocytes produce large amounts of this protein. The aim of...

  • Biosample Use Program, 2018
    MicroRNAs as Predictors and Measures of Parkinson's Disease

    Study Rationale:
    MicroRNAs (miRNAs) are molecules that control the production of proteins from genes in the cell. We have found that the blood of people with Parkinson's disease (PD) contains a lower...

  • Research Grant, 2018
    Inflammatory Phenotypes in Differentiated Human LRRK2 and GBA Mutation IPS Cell Lines

    Promising Outcomes of Original Grant:
    With previous funding from MJFF, we determined how the activity of LRRK2 genetic mutations contributed to inflammation in Parkinson's. We found that inflammation...

  • Research Grant, 2018
    Assess p935 LRRK2 and Total LRRK2 Levels Using an MSD Assay in Whole Blood

    Study Rationale:
    Some variants in the LRRK2 gene have been linked to increased risk of Parkinson's disease. This has made LRRK2 a promising target for Parkinson's drug development. To increase our...

  • Research Grant, 2018
    Autologous Long-Term Cell Restorative Therapy for Parkinson's Disease

    Study Rationale:
    Cell replacement using induced pluripotent stem cells (iPSCs) is a potential restorative therapy for Parkinson's disease. Replacing brain cells that produce dopamine, a chemical...

  • Research Grant, 2018
    Clinicopathological Correlates in LRRK2-Related Parkinson's Disease

    Promising Outcomes of Original Grant:
    With previous funding from MJFF, we established the largest collection of clinically characterized autopsies from Parkinson's patients with a LRRK2 mutation, from...

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Our funding programs support basic, translational and clinical research from academia and industry.

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