The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2018Structure-Based Design of Small-Molecule Activators of Parkin
Promising Outcomes of Original Grant:
The protein Parkin requires activation by another enzyme called PINK1. With previous MJFF funding, we identified a new class of chemical fragments that could be... -
Target Advancement Program, 2018Validating Astrocyte-produced Protein GDF15 as a Novel Neuroprotective Therapy
Study Rationale:
In Parkinson's disease (PD), death of dopamine-producing brain cells takes place mainly the substantia nigra pars compacta (SN) but not in the neighboring ventral tegmental area (VTA)... -
Target Advancement Program, 2018Testing the Ability of Clenbuterol to Prevent or Modify the Course of Parkinson's Disease
Study Rationale:
Protein alpha-synuclein clumps in the brains of people with Parkinson's disease (PD), forming Lewy bodies. Recent studies have suggested that beta-2 adrenoreceptor agonists -- drugs... -
Mitochondrial Biomarkers Program, 2018Changes in Mitochondrial DNA as Diagnostic and Progression Biomarkers of Parkinson's Disease
Study Rationale:
Biomarkers, or objective measures, of Parkinson's disease (PD) could help identify individuals at risk of PD and predict disease progression. According to recent studies, changes in... -
Inflammation Biomarkers Program, 2018The Kynurenine Pathway as a New Therapeutic Target and Source of Biomarkers for Parkinson's Disease
Study Rationale:
Inflammation is involved in the death of brain cells in Parkinson's disease (PD), but the exact relationship between the two is unclear. We propose that inflammation damages the brain... -
Inflammation Biomarkers Program, 2018Can Brain Inflammation Predict Dementia Associated with Parkinson's Disease?
Study Rationale:
For the reasons not well understood, people with Parkinson's disease are at risk for developing dementia, a decline in memory, thinking and/or language abilities severe enough to...
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Our funding programs support basic, translational and clinical research from academia and industry.