The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Target Validation, 2014CISD1 (mitoNEET) as a Mitochondrial Drug Target in Parkinson’s Disease
Objective/Rationale:
Mitochondrial dysfunction and oxidative stress contributes to the death of the brain cells seen in Parkinson’s disease. The mitochondrial protein mitoNEET (encoded by the gene... -
Parkin Therapeutic Development, 2014Pharmacological Modulation of Parkin Expression and Function to Attenuate Mitochondrial Dysfunction
Objective/Rationale:
This project aims to identify drug-like molecules that increase the amount of the protein parkin in neuronal cells. Parkin is mutated in some people with Parkinson’s disease (PD)... -
Rapid Response Innovation Awards, 2014Regulation of Alpha-synucleinopathy by BPOZ-2
Objective/Rationale:
BPOZ-2 is an anti-tumor protein that has been reported to stimulate the removal of cancer- related protein aggregates in cancer cells. However, its role has never been... -
Research Grant, 2014Detection of Alpha-Synuclein Oligomers for the Diagnosis of Parkinson's Disease
Study Rationale:
Parkinson's disease (PD) is associated with the presence of protein aggregates in the form of Lewy bodies composed of the protein alpha-synuclein. One of the... -
Rapid Response Innovation Awards, 2014Microvesicles: Biomarker and Vehicle for the Propagation of Pathological Forms of Alpha-synuclein
Study Rationale:
All living cells release extracellular vesicles composed of membrane proteins and lipids as well as components of the cell. These vesicles are important in cell-to-cell communication... -
Rapid Response Innovation Awards, 2014Role of Nicotinamide N-methyltransferase in Genetic Models of Parkinson’s Disease
Study Rationale:
There is mounting evidence linking the metabolism of the vitamin niacin to Parkinson’s disease (PD). The enzyme nicotinamide N-methyltransferase (NNMT), a key enzyme of the niacin...
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Our funding programs support basic, translational and clinical research from academia and industry.