The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutic Pipeline Program, 2014Liver X Receptor Agonists as Novel Therapeutics for Parkinson’s Disease
Study Rationale:
Inflammation is an early and characteristic feature of Parkinson’s disease. Recent studies connect a protein called the liver X receptor (LXR) to inflammation in key... -
Target Validation, 2014Dual GluK1/GluK3 Antagonism as a Neuroprotective Target
Objective/Rationale:
Over activation of glutamate receptors may contribute to the loss of dopamine cells in Parkinson’s disease (PD). Research suggests that drugs that target these... -
Rapid Response Innovation Awards, 2014Neuroimaging Carriers of the Alpha-synuclein E46K Mutation as a Model of Idiopathic Lewy Body Disease
Study Rationale:
In 2004 our group described, for the first time in literature, the E46K mutation of the alpha-synuclein gene in a family from the Basque region of Spain. The rare E46K mutation is... -
Alpha-synuclein Pathology, 2014Development of Diagnostic Biomarker Tests for Parkinson’s Disease
Study Rationale:
An early diagnostic test to identify those with Parkinson’s disease (PD) and to intervene with therapies as early as possible is a critical unmet need. Recent studies have... -
Research Grant, 2014Development and Validation of Biomarker Assays for Improved Diagnosis of Parkinson’s Disease: The Second Generation of Synuclein Assays
Study Rationale:
Lewy bodies composed primarily of the protein alpha-synuclein are important hallmarks of Parkinson’s disease (PD). Available data on the clinical use of alpha... -
Research Grant, 2014Genetic Predictors of Prognosis: GBA and SNCA Meta-Analysis Project
Study Rationale:
Predicting the prognosis of Parkinson’s disease (PD) for a patient is currently not possible. Genetic predictors of prognosis would help inform clinical trial design...
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Our funding programs support basic, translational and clinical research from academia and industry.