The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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MJFF Research Grant, 2010Coordinated Reset (CR) Stimulation of the Subthalamic Nucleus
Objective/Rationale:
Coordinated Reset (CR) stimulation improved locomotor activity in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin (MPTP)-treated pre-clinical model in a “proof of concept” study... -
MJFF Research Grant, 2010Establishing an LRRK2 Signaling Pathway and Assays for Patient Derived Samples
Objective/Rationale:
Inherited mutations in a gene called LRRK2 have been found to cause Parkinson ’s disease. The LRRK2 gene encodes an enzyme called a kinase, for which no exact function has been... -
MJFF Research Grant, 2010Development of an Assay to Detect LRRK2 Protein in Biological Samples
Objective/Rationale:
LRRK2 (Leucine-Rich Repeat Kinase 2) is a protein thought to be involved in regulating signaling pathways in cells. Mutations in the gene for LRRK2 are associated with some... -
MJFF Research Grant, 2010Intranasal GDNF for Parkinson's Disease: Next Steps in Preclinical Development
Objective/Rationale:
GDNF, a “growth factor” capable of promoting the survival of dopamine neurons, has great potential as a treatment for Parkinson’s disease. However, getting GDNF into the brain has... -
Target Validation, 2011The Sigma 1 Receptor as a Target for Disease-modifying Therapies in Parkinson's Disease
Objective/Rationale:
The Sigma-1 receptor (Sig-1R) is a protein involved in the transport of lipids and proteins between organelles within the cell. Impairment of these intracellular trafficking... -
Target Validation, 2011Validation of Dorsal Column Electrical Stimulation as a Target for Parkinson's Disease Therapy
Objective/Rationale:
Direct electrical stimulation of certain areas of the brain is an effective method to treat the motor symptoms of Parkinson’s, but it requires the insertion of electrodes into the...
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Our funding programs support basic, translational and clinical research from academia and industry.