The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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MJFF Research Grant, 2009PD Pre-clinical Model Repository
Objective/Rationale:
The Michael J. Fox Foundation (MJFF) is partnering with The Jackson Laboratory (JAX) to distribute pre-clinical models of Parkinson’s disease (PD). MJFF funding will allow JAX to... -
Rapid Response Innovation Awards, 2009Phase I Trial of Phenylbutyrate to Prevent Progression of Parkinson's Disease
Objective/Rationale:
Parkinson’s disease gets worse over many years because dopamine neurons continue to die. Researchers have discovered a drug that prevents brain deterioration in pre-clinical... -
Rapid Response Innovation Awards, 2009Exploring Serotonergic Cortical Targets for Treatment of Parkinson's Disease Using a Mathematical Disease Model
Objective/Rationale:
Because animal models have limited predictability for clinical outcomes of experimental Parkinson drugs, a complex mathematical model of the interactions between key motor... -
Rapid Response Innovation Awards, 2009The Effect of 4-hydroxy-2-nonenal Modification on Alpha-synuclein Toxicity
Objective/Rationale:
Alpha-synuclein is a protein that is normally produced in the human brain. Compelling evidence suggests that alpha-synuclein can acquire a toxic feature that kills dopamine... -
Rapid Response Innovation Awards, 2009Aldehyde Dehydrogenase Activators as Novel Drugs For the Treatment of PD
Objective/Rationale:
The accumulation of at least two toxic products in the brain called DOPAL and 4HNE results in death of neurons that are implicated in Parkinson’s Disease (PD). We identified a... -
Rapid Response Innovation Awards, 2009Enzymes that Catalyze for Alpha-synuclein Ubiquitination and Degradation
Objective/Rationale:
A characteristic feature of Parkinson’s disease (PD) is the buildup of the protein, alpha-synuclein, and overproduction of this protein can trigger PD. Therefore, it is important...
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Our funding programs support basic, translational and clinical research from academia and industry.