The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Rapid Response Innovation Awards, 2008The Role of the Unfolded Protein Response (UPR) in Parkinson's Disease
Objective/Rationale:
Our general objective is to investigate the role of the cellular stress responses linked to organelle damage such as the Unfolded Protein Response in the development of Parkinson... -
Rapid Response Innovation Awards, 2008A Novel Cell Model for LRRK2 Parkinson's Disease
Objective/Rationale:
The aim of this project is to create a model of Parkinson’s disease using skin cells from patients who have an inherited form of Parkinson’s disease. Using newly developed stem... -
Rapid Response Innovation Awards, 2008Identification of binding proteins for alpha-synuclein oligomers in brain and cells
Mutations in the PARK-1 and PARK-4 genes leads to alpha-synuclein aggregation with pathology eventually resembling that of sporadic PD. One question is whether the insoluble form of alpha-synuclein is...
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Target Validation, 2007Validation of Sirtuin 2 Deacetylase as a Therapeutic Target in Parkinson’s disease
Objective/Rationale:
A major known risk factor in Parkinson’s disease is the misfolding, aggregation and abnormal accumulation of the protein alpha-synuclein. The goal of the proposed work is to... -
Rapid Response Innovation Awards, 2007Understanding the Role of Glucocerebrosidase in Parkinson's Disease Pathogenesis: Toward a New Genetic Model of Sporadic PD
Gaucher’s disease is a glycosphingolipid-storage disease in which homozygous mutations are found in the lysosomal enzyme glucocerebrosidase (GBA) gene. PD and Gaucher’s disease share many clinical and...
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Rapid Response Innovation Awards, 2007Target Identification of the Mitochondrial Parkinson's Disease PTEN-Induced Kinase 1
Mutations in PINK1 can cause Parkinson’s disease in certain familial PD cases. The exact cellular function of PINK1 and the impact of disease-relevant mutations remain unknown. PINK1 is known to...
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Our funding programs support basic, translational and clinical research from academia and industry.