The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Synuclein Therapeutic Acceleration Program, 2013Quinpramine for Parkinson’s Disease
Objective/Rationale:
A part of Parkinson’s disease progression involves abnormal aggregation of normal brain proteins into knots of insoluble irritant material. The protein involved in... -
Therapeutic Pipeline Program, 2013Development of Trehalose as a Disease-modifying Treatment for Parkinson’s Disease
Objective/Rationale:
The development of Parkinson’s disease (PD) is linked to the accumulation of the toxic protein alpha-synuclein. Systems within neurons able to clear alpha-synuclein... -
Biosample and Tissue Resource, 2013From Genetic Risk Toward Genetic Prognosis
Objective/Rationale:
The progression and prognosis of Parkinson’s disease (PD) varies considerably between individual patients — ranging from a manageable, functional decline to an aggressive course... -
Research Grant, 2013Development of Highly Sensitive Immunoassays for pS129 Alpha-synuclein in Human Samples
Objective/Rationale:
The development of disease-modifying therapies in Parkinson’s disease requires the availability of quantitative biomarkers for use in primary diagnosis, monitoring... -
LRRK2 Pharmacodynamic Assays, 2013Measuring LRRK2 Phosphorylation by Flow Cytometry
Objective/Rationale:
There is a possibility that inhibitors of the leucine-rich repeat kinase 2 (LRRK2) protein could be used for treating Parkinson’s disease. Our projects aims to develop... -
LRRK2 Cohort Consortium Resource Request, 2013Penetrance of LRRK2 in the LRRK2 Cohort Consortium
Objective/Rationale:
Estimates for development of Parkinson’s disease (PD) and age of onset in carriers of LRRK2 G2019S mutations vary widely (24 to 100% by age 80). Factors including...
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Our funding programs support basic, translational and clinical research from academia and industry.