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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Therapeutic Pipeline Program, 2015
    Improving Access to Depression Care in Parkinson’s Disease: A Telehealth Approach

    Study Rationale:                   
    There is a critical need for treatments that address depression and barriers to care among the approximately 5 million people living with Parkinson’s disease (PD)...

  • Biomarker Development, 2015
    Comparison of Pre- and Post-mortem Cerebrospinal Fluid Levels of Proteins and Lipids

    Study Rationale:                   
    Alpha-synuclein aggregation in the brain is the main pathology of Parkinson’s disease (PD). Cerebrospinal fluid (CSF) levels of alpha-synuclein are lower in PD. It...

  • Dyskinesia Challenge, 2015
    Biomarkers and Sensors for Levodopa-induced Dyskinesia

    Study Rationale:                   
    Levodopa is the gold-standard drug for treatment of Parkinson’s disease (PD), but chronic use is associated with serious motor complications called levodopa-induced...

  • Dyskinesia Challenge, 2015
    Targeting M4 Muscarinic Receptors for the Treatment of Levodopa-induced Dyskinesia

    Study Rationale:                   
    Levodopa-induced dyskinesia is thought to stem from sustained stimulation of D1 dopamine receptors (D1Rs). One potential strategy for diminishing excessive D1R...

  • Access to Data and Biospecimens, 2015
    New Tools for Direct Visualization of Individual Oligomers in Human Biofluids

    Objective/Rationale: We have developed a completely new optical technique called SOAP imaging (single oligomers of amlyoidigenic proteins). This can be used to directly visualize the protein clumps...

  • Access to Data and Biospecimens, 2015
    BioFIND: Analysis of A-beta, Tau and P-tau in CSF Samples

    Study Rationale: Mixed pathology is common in all neurodegenerative diseases including Parkinson’s disease (PD).  Three cerebrospinal fluid (CSF) biomarkers, Ab1-42, t-tau and p-tau181, provide an...

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