The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Alpha-Synuclein Therapeutics, 2010Anti-amyloid Oligomer Monoclonal Antibodies for Treatment of Parkinson's Disease
Objective/Rationale:
The goal of this project is to evaluate the interaction of a panel of conformation dependent, aggregation specific anti-amyloid monoclonal antibodies with alpha-synuclein... -
Pharmacodynamic Biomarkers of LRRK2 Activity, 2010LRRK2 Dimerization as Pharmacodynamic Biomarkers of Activity
Objective/Rationale:
A promising target for neuroprotective therapies in Parkinson’s disease has emerged in the LRRK2 protein kinase. Proteins with similarities to LRRK2 have been successfully... -
Novel Hypotheses in Parkinson's Disease, 2010Quantitative Analysis of S-Nitrosylated Proteins in Parkinson's Disease
Objective/Rationale:
Free radical stress may play a role in pathogenesis of Parkinson’s disease (PD). In this project, we study how free radicals related to reactive nitrogen (N) and oxygen (O)... -
Understanding LRRK2 Biology, 2010Functional Analysis of LRRK2: Focus on Autophagy
Promising Outcomes of Original Grant:
The overall purpose of the original grant was to utilize pre-clinical and human model systems to better understand LRRK biology. The original aims proposed were to... -
Understanding LRRK2 Biology, 2010Biochemical characterization of full length human recombinant LRRK1 and LRRK2
Promising Outcomes of Original Grant:
In our initial application we proposed to take advantage of a lentiviral system recently developed in KULeuven to express full-length, soluble human LRRK1 and... -
Research Grant, 2010Longitudinal Follow-Up of Clinical and Neuroimaging Signs and Biomarkers in Symptoms & Side Effects and aSymptoms & Side Effects LRRK2 Mutation Carriers in Comparison to Idiopathic PD and Controls
Objective/Rationale:
Parkinson’s disease (PD) is a common neurodegenerative disease that leads to progressive motor impairment as well as autonomic and cognitive disturbances. The cause of most of...
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Our funding programs support basic, translational and clinical research from academia and industry.