The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Target Validation, 2007Functional Inhibition of RasGRF1 in the MPTP-lesioned NHP Model for Treating Levodopa-induced Dyskinesia
Objective/Rationale:
Levodopa-induced dyskinesias are caused by an increased and aberrant response of dopamine receptors to dopamine in the striatum. Among other intracellular pathways, the MAP kinase... -
Target Validation, 2007Validation of metabotropic glutamate-receptor type 5 as a target for the treatment of L-DOPA-induced dyskinesia in a macaque model of Parkinson´s disease
Objective/Rationale:
Metabotropic glutamate receptor type 5 (mGluR5) is abundantly expressed in striatal neurons, where it modulates the response to glutamatergic and dopaminergic inputs. Previous... -
Target Validation, 2007Inhibition of c-Abl Tyrosine Kinase as a Novel Therapy to Prevent PD ProgressionObjective/Rationale: Mutations in the parkin gene cause early-onset autosomal recessive PD. We have discovered that parkin is modified by an oxidative-stress induced signaling kinase, c...
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Rapid Response Innovation Awards, 2007Unraveling the genetic basis for alpha-synuclein oligomerization in living cells using bimolecular fluorescence complementation
Oligomerization of alpha-synuclein is hypothesized to be the pathogenic mechanism of protein aggregate formation and cell death in neurons of PD patients. Dr. Outeiro proposes to develop an assay to...
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Community Fast Track, 2007Gene Therapy for Parkinson's Disease: Does Re-expression of HCN2 in GPe Improve Motor Deficits in Rodent PD Model?
Promising Outcomes of Original Grant:
We hypothesized that dopamine depletion in Parkinson’s disease results in downregulation of a specific ion channel, termed HCN2, in neurons of the external... -
Community Fast Track, 2007Elucidating the Role of Nurr1 in Protection of Adult Dopamine Neurons of the Substantia Nigra
Promising Outcomes of Original Grant:
Nurr1 is a transcription factor that is known to be important for the development of dopamine neurons. However, it continues to be expressed also in the adult...
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Our funding programs support basic, translational and clinical research from academia and industry.