The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Improved Biomarkers and Clinical Outcome Measures, 2016Supramolecular Hosts as Combined Protein Aggregation Inhibitors and Hyperpolarized MRI Reporters
Study Rationale:
Amyloid fibrils play a key role in Parkinson's disease (PD) and monitoring of their formation from self‐assembled insoluble molecular aggregates would be extremely valuable as a... -
Research Grant, 2016Parkinson's Disease Genetics Sequencing Consortium
Study Rationale:
The Parkinson's Disease Genetics Sequencing Consortium (PDGSC) was established following a National Institute of Neurological Disorders and Stroke workshop in June 2014 and brings... -
Research Grant, 2016Rab Detection Initiative and LRRK2 Detection Initiative Supplemental Support RDI, and LCC exosome replication
Study Rationale:
The LRRK2 detection initiative (LDI) and Rab detection initiative (RDI) are focused on developing techniques for the robust and sensitive detection of LRRK2, phospho-LRRK2, Rab and... -
Research Grant, 2016LRRK2 Biomarker Initiative: Detection of LRRK2 in Cerebrospinal Fluid
Study Rationale:
Recent studies indicate the potential use of LRRK2 or LRRK2 phosphorylation (protein regulation) in biosamples as disease markers or as markers of response to novel therapeutics... -
Research Grant, 2016Mechanisms of LRRK2 Membrane Association
Promising Outcomes of Original Grant:
We have verified that LRRK2 undergoes key changes that affect LRRK2 structure and LRRK2 membrane localization. We have generated a large set of LRRK2 variants... -
Target Advancement Program, 2016LRRK2 Mutations and the Development of Therapeutic LRRK2 Inhibitors
Study Rationale:
Mutations in the leucine-rich repeat kinase 2 (LRRK2) protein can cause an inherited form of Parkinson's disease (PD). Understanding how these mutations cause PD is complicated, as...
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Our funding programs support basic, translational and clinical research from academia and industry.