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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • MJFF Research Grant, 2012
    Analysis of Archived Tissue from Parkin, DJ-1, PINK1 and LRRK2 KO Pre-Clinical Models

    Objective/Rationale:             

    As part of a broad effort to develop preclinical models of Parkinson’s disease (PD), MJFF sponsored the generation and initial characterization of knockout pre...

  • MJFF Research Grant, 2012
    Novel PD Tools: Generation of Posttranslationally Modified Alpha-synuclein

    Objective/Rationale:             
    There is increasing evidence linking specific posttranslational modification (folding, cutting, etc. of proteins before maturation) and alpha-synuclein aggregation...

  • Target Validation, 2012
    Validating Monoacylglycerol Lipase Inhibitors in Combatting Parkinson’s Disease

    Objective/Rationale:             
    Chronic and persistent inflammation in the brain has been shown to be an underlying driver of Parkinson’s disease (PD). Anti-inflammatory strategies may be beneficial...

  • Dyskinesia Challenge, 2012
    Evaluation of Cortical Resonant Oscillations as a Novel Target for Treatment of Dyskinesia

    Objective/Rationale:             
    In our research we aim to identify changes in neuronal circuits that cause motor symptoms in Parkinson’s disease (PD) by recording neuronal activity in healthy and in...

  • Dyskinesia LEAPS, 2012
    Topiramate as an Adjunct to Amantadine in the Treatment of Dyskinesia in Parkinson's Disease

    Objective/Rationale: 
    Dyskinesia is a term used to describe involuntary movements that develop as side effects of dopamine drugs used to treat Parkinson's disease. Dyskinesias are frequent and...

  • Research Grant, 2012
    The Transfer of Alpha-Synuclein: Mechanistic and Therapeutic Studies

    Objective/Rationale:
    This three-year collaborative project between three seasoned Parkinson’s disease (PD) investigators capitalizes on their extensive PD research experience and new understanding of...

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