The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Neurotrophic Factors Challenge, 2012Novel Cell-based Strategy for GDNF Delivery in Parkinson's Disease
Objective/Rationale:
Glial cell line-derived neurotrophic factor (GDNF) is the most potent nerve cell growth molecule capable of protecting the dopamine neurons that are affected in... -
LRRK2 in the Immune System, 2012Investigation of Neuroinflammation in LRRK2 Mutation Carriers Using Positron Emission Tomography
Objective/Rationale:
There is evidence that LRRK2 mutation may alter the immune response in such as way as to potentiate neuroinflammatory responses to external triggers, with a... -
Rapid Response Innovation Awards, 2012Targeting of 5-HT1A and 5-HT2A Receptors Against Levodopa-induced Dyskinesia
Objective/Rationale:
Levodopa continues to be the gold-standard therapy for patients with Parkinson’s disease (PD). Unfortunately, effective long-term treatment is beset by abnormal... -
Biomarker Development, 2012VILIP-1 as Diagnostic and Prognostic Biomarker for Parkinson's Disease
Objective/Rationale:
Novel biomarkers are key for successful clinical development of Parkinson’s therapies. In Alzheimer’s disease the calcium sensing protein VILIP-1 (visinin-like... -
Therapeutics Development Initiative, 2012Potential of Novel Insulin Sensitizers to Treat Dyskinesia
Objective/Rationale:
The goal of this project is to determine whether the mTOT insulin sensitizer, MSDC-0160, can both prevent (when given at the same time) or reverse (when given later)... -
MJFF Research Grant, 2012Non-kinase Targets in LRRK2 Biology
Objective/Rationale:
We aim to understand how mutations in one gene, LRRK2, lead to Parkinson’s disease. We will do this by focusing on one region of the protein that has not had much...
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Our funding programs support basic, translational and clinical research from academia and industry.