The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Alpha-synuclein Seed Amplification Assay Program, 2022Digital Detection of Alpha-synuclein Aggregates for the Quantitative Diagnosis of Parkinson’s disease
Study Rationale: The detection of protein aggregates is currently at the leading edge of diagnostic developments in Parkinson’s disease and other age-related disorders. There is demand for...
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Fall 2021 RFP: Outcome Measures, 2022Common Mitochondrial DNA Deletions as a Peripheral Marker of Parkinson’s Disease
Study Rationale: Mitochondria are small capsules inside cells that generate energy. There are lots of mitochondria in brain cells because the brain uses a lot of energy. Researchers have found that...
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Research Grant, 2022Expanding Genetic Analyses in Parkinson’s Disease
Study Rationale: There is a critical need for greater understanding of the genetic component of Parkinson’s disease, both to predict and diagnose disease, but also to inform drug development efforts...
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Fall 2021 RFP: Accelerating Early Proof-of-Concept Testing of Promising PD Therapies, 2022Using AZP2006 (Ezeprogind) to Stabilize Progranulin – A Novel Therapeutic Strategy for GBA1-linked Parkinson’s Disease
Study Rationale: Progranulin (PGRN) regulates cell growth, survival and changes. They are usually secreted or transported to the lysosome. Its deficiency and inflammation leads to a decline in the...
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Research Grant, 2022Development And Validation Of A Miro1 Biomarker Assay Using White Blood Cells
Study Rationale: The mitochondrial protein Miro1 fails to be degraded and this defect impairs mitophagy in more than 90% of all Parkinson’s disease (PD) patients of both genetic and sporadic forms...
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Research Grant, 2022RT-QuIC Testing of Misfolded α-Synuclein in Stage 4 Study; Submandibular Gland Biopsies and CSF Samples
Study Rationale: Normally folded a-synuclein protein is vital to normal brain function. However, misfolded a-synuclein can form the aggregated fibrils that contribute to Parkinson’s disease’s (PD)...
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Our funding programs support basic, translational and clinical research from academia and industry.