The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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GBA Biology and Therapies, 2018Live Cell Image-based Screening and Validation of Glucocerebrosidase Activators
Study Rationale:
Changes in the gene GBA that cause malfunction of a protein known as glucocerebrosidase (GCase) are found in about 10 percent of Parkinson’s disease (PD) patients. Even those PD... -
GBA Biology and Therapies, 2018Role of GBA in Mitochondrial Antigen Presentation
Study Rationale:
Parkinson’s disease is caused by the death of dopaminergic neurons in the brain. We propose that the immune system plays a key role in the death of dopaminergic neurons during PD via a... -
GBA Biology and Therapies, 2018Assessing TRPML1 Agonists in GBA Parkinson’s Disease
Study Rationale:
Lysosomes are small compartments that function as the garbage disposal of the cells, eliminating toxic accumulations. Malfunction of these organelles impact the clearance of waste... -
GBA Biology and Therapies, 2018Investigation of Small Molecules to Rescue Lysosomal and GBA Deficiencies in GBA PD
Study Rationale:
Individuals with mutations in the GBA gene have a higher risk of Parkinson’s disease (PD) and another genetic condition: Gaucher disease. GBA mutations lower activity of the protein... -
GBA Biology and Therapies, 2018Compromised Lysosomal Lipid Flippase Activity in Parkinson’s Disease
Study Rationale:
The lysosome is an important compartment in cells that degrades obsolete components, such as the lipid glucosylceramide (GC). The degradation of GC depends on the enzyme... -
GBA Biology and Therapies, 2018Structural Characterization of the GCase/LIMP-2 Complex
Study Rationale:
Mutations in the GBA gene are a risk factor for Parkinson’s disease (PD) and cause deficits in the protein GCase. GCase reaches its final destination in the cell, the lysosome, via its...
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