The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Target Advancement Program, 2016Insights into LRRK2 Kinase Inhibitors
Study Rationale:
Mutations in LRRK2 cause an inherited form of Parkinson's disease (PD), and variations in LRRK2 can increase disease risk, indicating that the protein is key in the entire PD disease... -
Therapeutic Pipeline Program, 2016Novel LRRK2 Antisense Oligonucleotides as a Therapy for Parkinson's Disease
Study Rationale:
LRRK2 gain-of-function gene mutations (R1441C and G2019S) are one of the most prevalent mutations contributing to inherited Parkinson's disease (PD). Altered LRRK2 function has also... -
Target Advancement Program, 2016The Role of LRRK2 in Neuronal Calcium Maintenance
Study Rationale:
Calcium is essential for neuronal survival and function. Flawed intracellular calcium homeostasis (maintenance) is linked to neurodegeneration. There is, however, a major knowledge... -
Research Grant, 2016Tau Imaging in Parkinson's Disease
Study Rationale:
A substantial proportion of individuals with Parkinson's disease develop cognitive
impairment, or difficulty with thinking abilities. The basis for these changes is poorly
understood. We... -
Research Grant, 2016Clinicopathological Features of LRRK2-related Parkinson's Disease
Study Rationale:
Lewy bodies are aggregates of protein composed primarily of alpha-synuclein. For a century, Lewy bodies in the brain have been known to be a defining pathological feature of Parkinson... -
Target Advancement Program, 2016Role of LRRK2 in Levodopa-induced Dyskinesia
Study Rationale:
Alterations in the gene LRRK2 are associated with inherited forms of Parkinson's disease (PD). Although it remains unclear why changes in LRRK2 cause the disease, the majority of...
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Our funding programs support basic, translational and clinical research from academia and industry.