The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2016Mechanisms of LRRK2 Membrane Association
Promising Outcomes of Original Grant:
We have verified that LRRK2 undergoes key changes that affect LRRK2 structure and LRRK2 membrane localization. We have generated a large set of LRRK2 variants... -
Target Advancement Program, 2016LRRK2 Mutations and the Development of Therapeutic LRRK2 Inhibitors
Study Rationale:
Mutations in the leucine-rich repeat kinase 2 (LRRK2) protein can cause an inherited form of Parkinson's disease (PD). Understanding how these mutations cause PD is complicated, as... -
Research Grant, 2016Evaluation of LRRK2 Kinase Activity in Blood Cells
Promising Outcomes of Original Grant:
Since LRRK2 is a major genetic risk factor for Parkinson's disease (PD), much work has been devoted to LRRK2 function in neurons. However, LRRK2 is abundantly... -
Research Grant, 2016MJFF Recruitment Centers of Excellence
Study Rationale:
Clinical trials and studies in Parkinson's disease (PD) are often limited by low enrollment of participants , increasing the time it takes to bring new therapies to the market. The... -
Research Grant, 2016Inhibition of Striatal-enriched Phosphate (STEP) to Improve Parkinson-related Cognitive Dysfunction
Promising Outcomes of Original Grant:
Our original funded project was designed to examine absorption and distribution of the STEP (Striatal-Enriched Phosphatase), a protein associated with several... -
Target Advancement Program, 2016Studying Monocyte Entry into the Brain in Alpha-synuclein-induced Parkinson's Disease
Study Rationale:
Alpha-synuclein is a sticky protein that clumps in the brains of people with Parkinson's disease (PD). In pre-clinical models, alpha-synuclein clumps attract scores of CCR2-positive...
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Our funding programs support basic, translational and clinical research from academia and industry.