The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
-
Target Advancement Program, 2016Mechanism of TFEB Dysfunction by GBA1 Mutation in Human iPSC-derived Dopaminergic Neurons
Study Rationale:
People who have mutations in the GBA1 gene have a higher chance of developing Parkinson's disease (PD) but it is unclear why. We found that GBA1 mutations affect the cellular ability... -
PPMI Data Challenge, 2016Subtyping Parkinson’s Disease with Deep Learning Models (2016 PPMI Data Challenge Winner)
Study Rationale:
As Parkinson's disease (PD) is highly heterogeneous, identifying coherent PD subtypes is crucial for understanding the underlying mechanism of the disease and designing and testing... -
PPMI Data Challenge, 2016Multivariate Prediction of Parkinson's Disease Clinical Progression (2016 PPMI Data Challenge Winner)
Study Rationale:
Parkinson's disease (PD) is heterogeneous in both clinical representation and prognosis, as indicated by a large diversity of rates of progression in motor as well as non-motor... -
Research Grant, 2016GBA Meta-analysis Initiative: Charting a Path to Success for Clinical Trials in Patients with GBA-PD
Promising Outcomes of Original Grant:
We ascertained the associations between GBA mutations and cognitive and motor outcomes in seven large cohorts representing 2,304 patients with PD (including 221... -
Therapeutic Pipeline Program, 2016Blocking Inflammasome-induced Neuroinflammation in Parkinson's Disease with a Potent, Orally Available Small Molecule
Study Rationale:
Our brains are full of immune cells called microglia, which fight infections and clear the brain of toxic products. In Parkinson's disease, these cells are constantly active, leading... -
Target Advancement Program, 2016Pharmacological Targeting of Proinflammatory Kinase Signaling in Parkinson's Disease
Study Rationale:
In Parkinson's disease, the brain's resident immune cells, called microglia, can become persistently activated due to the accumulation of alpha-synuclein-containing protein clumps...
Apply for a Grant
Our funding programs support basic, translational and clinical research from academia and industry.