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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2016
    Patient-Carer-Provider Communication about the Impact of Motor and Non-motor Fluctuations

    Study Rationale:
    Temporary periods of poor mobility and other symptoms (OFF periods) are common in Parkinson’s disease and are associated with poorer quality of life. OFF symptoms are complex, with...

  • Improved Biomarkers and Clinical Outcome Measures, 2016
    Developing New Method for GBA sequencing and Detection of Germ-line or Somatic Point Mutations, Deletion/Insertions and Recombinations with the GBA Pseudo Gene

    Study Rationale:                   

    Mutations in the GBA gene are the most common genetic cause of Parkinson’s disease. This gene has a nearby pseudogene, which is a genetic material that is very...

  • Improved Biomarkers and Clinical Outcome Measures, 2016
    Supramolecular Hosts as Combined Protein Aggregation Inhibitors and Hyperpolarized MRI Reporters

    Study Rationale:
    Amyloid fibrils play a key role in Parkinson's disease (PD) and monitoring of their formation from self‐assembled insoluble molecular aggregates would be extremely valuable as a...

  • Access to Data and Biospecimens, 2016
    Evaluation of Glucocerebrosidase Pathway Biomarkers in Parkinson's Disease

    Study Rationale: 

    Parkinson disease (PD) due to monoallelic glucocerebrosidase (GBA1) gene mutations (GBA-PD) is at the forefront of novel approaches to the treatment of PD. Exciting potential...

  • Research Grant, 2016
    Identification of Epigenetic Signatures in Blood as Biomarkers for Parkinson's Disease

    Study Rationale:
    Epigenetic processes (changes in gene expression), such as DNA methylation (mechanism that cells use to control gene expression), ensure proper functioning of genetic materials in...

  • Biomarker Development, 2015
    Development of Novel, Small Molecule Compounds as PET Tracers for Synucleinopathies

    Study Rationale:
    Our project aims to develop a brain imaging agent for alpha-synuclein, a key protein involved in Parkinson’s disease (PD) pathology. Such an agent will help (i) diagnose PD earlier,...

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