The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutics Development Initiative, 2009Design of Neuroprotective Drugs to Reduce Oxidative Damage and Alpha-synuclein Toxicity in Parkinson's Disease
Objective/Rationale:
Exposure to chemical toxins that stimulate the production of reactive oxygen and nitrogen species (RONS) causes neuronal degeneration and can lead to Parkinson’s disease (PD)... -
Therapeutics Development Initiative, 2009Developing Autophagy Enhancers as Disease-modifying Therapeutics for Parkinson's Disease
Objective/Rationale:
We seek to develop small molecule drugs that promote the cellular process of autophagy as disease-modifying therapy for Parkinson's disease (PD). Autophagy is a highly conserved... -
Therapeutics Development Initiative, 2009Determination and Validation of the Molecular Target of J3, a Neuroprotective Lead Compound, for Its Optimization as a Disease-modifying Candidate for Parkinson's Disease
Objective/Rationale:
We have identified a small molecule, designated J3, which shows promising neuroprotection in an acute animal model of Parkinson’s disease (PD). To reach our ultimate goal of... -
Biomarkers, 2009Development of an alpha6*-Selective Neuronal Nicotinic Receptor (NNR) Imaging Agent as a Parkinson's Disease Biomarker
Objective/Rationale:
The availability of a selective PET radiotracer for the drug target is critical for determining receptor occupancy in humans. NNR subtypes containing the alpha? subunit have been... -
Biomarkers, 2009High Resolution Diffusion Tensor Imaging in Parkinson's Disease and Parkinson Plus Syndromes
Objective/Rationale:
An objective and valid trait and state biomarker of Parkinson’s disease will help therapeutic development by providing a measure to help confirm diagnosis (trait), and track... -
Rapid Response Innovation Awards, 2009Possibility of Small Molecule Activation of PINK1 Kinase Activity
Objective/Rationale:
Many genetic disorders are caused by the loss of a functional protein which protects cells from disease. These disorders are difficult to treat with drugs because most drugs block...
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Our funding programs support basic, translational and clinical research from academia and industry.