The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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MJFF Research Grant, 2008DNA Nanoparticle Therapy for Parkinson’s Disease
Promising Outcomes of Original Grant:
Recombinant plasmid DNA encoding for glial cell line-derived neurotrophic factor (GDNF) was compacted into nanoparticles, injected safely into the brain, and... -
Rapid Response Innovation Awards, 2008Development of modulators of alpha-synuclein conformation for PD therapeutics
Promising Outcomes of Original Grant:
Our Rapid Response Innovation Award (RRIA) enabled us to develop a conformational change assay for monomeric alpha-synuclein. We identified positive and negative... -
Cognitive Deficits and Mood Disorders in Parkinson's Disease, 2008A Rodent Model of Pathological Gambling Associated with Medicated Parkinsonian Patients
Objective/Rationale:
The increase in impulsive and risky behaviors, like gambling, hyper-sexuality, and compulsive shopping are emotionally and financially devastating, and impose a significant burden... -
Cognitive Deficits and Mood Disorders in Parkinson's Disease, 2008Cognitive Decline in Parkinson's Disease
Objective/Rationale:
There are many studies on cognitive and behavioral alterations in Parkinson’s disease, but each of these investigations brought only a small piece of a large puzzle. Consequently... -
Program-non-specific Funding, 2008Validation of TorsinA as a Target for PD Therapy in Mammalian Models
Objective/Rationale:
Mutations in the protein torsinA cause a hereditary form of dystonia. While the normal function of torsinA is not entirely clear, it is thought to be a “chaperone,” a molecule... -
Rapid Response Innovation Awards, 2008Exploring a Novel Pathogenetic Mechanism in Parkinson's Disease
Objective/Rationale:
We recently reported that neuropathological changes gradually propagate from Parkinson disease patients’ brains to grafted neurons. Over one decade after graft surgery, we found...
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Our funding programs support basic, translational and clinical research from academia and industry.