The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Rapid Response Innovation Awards, 2010Generation of a Novel Recombinant Protein Activator of GPR88
Objective/Rationale:
Dopamine replacement therapy activates neurons in a particular region of the brain, the striatum, leading to an improvement in disease symptoms. This action occurs through a... -
Rapid Response Innovation Awards, 2010Circulating microRNAs as Biomarkers for Early Detection of Parkinson's Disease
Objective/Rationale:
MicroRNAs (miRNAs) are small, conserved RNAs that interact with target sequences on messenger RNAs. MiRNAs have been proven to regulate the expression of many genes and play... -
MJFF Research Grant, 2010Generating and Characterizing LRRK2 Antibodies
Objective/Rationale:
LRRK2 is a gene implicated in the development of some familial Parkinson’s disease cases. Because of LRRK2’s significant potential as a drug target, MJFF is making considerable... -
MJFF Research Grant, 2010Comparison and Actions of MANF and GDNF in Rodent Models of Parkinson's Disease
Objective/Rationale:
Parkinson's disease (PD) is caused by the degeneration of certain dopaminergic neurons in the brain. Neurotrophic factors like GDNF protect dopaminergic neurons from degenerating... -
MJFF Research Grant, 2010Viral Over-expression of Alpha Synuclein
Promising Outcomes of Original Grant:
In our previous grant, we attempted to create a bilateral model of PD using viral over expression of alpha-synuclein. The performance of the study was near... -
MJFF Research Grant, 2010A Rodent Model of Pathological Gambling Associated with Medicated Parkinsonian Patients
Promising Outcomes of Original Grant:
In keeping with our original hypothesis, we determined the following: 1) Being in a parkinsonian state (i.e., following 6-OHDA-induced lesions) alters impulsivity...
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Our funding programs support basic, translational and clinical research from academia and industry.