The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Alpha-Synuclein Therapeutics, 2010A Pre-Clinical Study in a PD-like Transgenic Pre-Clinical Model of a Novel Isoindole Compound that Selectively Blocks Alpha-Synuclein Oligomerization
Objective/Rationale:
The damage to neuronal cells and connections in Parkinson’s disease is associated with the abnormal accumulation of a neuronal protein denominated alpha-synuclein. We have... -
Alpha-Synuclein Therapeutics, 2010Morphology Specific Anti-Synuclein Nanobodies as Therapeutics for PD
Objective/Rationale:
Aggregation and deposition of the protein, a-synuclein (a-syn), has been strongly correlated with PD and other related neurodegenerative disorders. The a-syn protein occurs in a... -
Rapid Response Innovation Awards, 2010Is glucose metabolism perturbed in PD?
Objective/Rationale:
Glucose metabolism is of central importance in maintaining the anti-oxidant ability of neurons to protect themselves from internal and external damage. When glucose metabolism is... -
Rapid Response Innovation Awards, 2010Immuno-PCR Detection of Alpha-Synuclein Phosphorylated at Serine-129 as PD Biomarker
Objective/Rationale:
At present, the definite diagnosis of PD can be made only after death by examining the pathology in brain of deceased patients. Diagnosis assesses the presence of clumps within... -
MJFF Research Grant, 2010PROGENI Family Study
Objective/Rationale:
The LRRK2 Consortium is designing studies to allow researchers to identify the key genetic, biological and clinical features of LRRK2 associated PD that could lead to improved... -
Alpha-Synuclein Therapeutics, 2010Anti-amyloid Oligomer Monoclonal Antibodies for Treatment of Parkinson's Disease
Objective/Rationale:
The goal of this project is to evaluate the interaction of a panel of conformation dependent, aggregation specific anti-amyloid monoclonal antibodies with alpha-synuclein...
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Our funding programs support basic, translational and clinical research from academia and industry.