The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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MJFF Research Grant, 2010Characterization of an Inhibitor Compound of LRRK2 Function
Objective/Rationale:
LRRK2 (Leucine-Rich Repeat Kinase 2) is a protein thought to be involved in regulating signaling pathways in cells. Mutations in the gene for LRRK2 are associated with some... -
Research Grant, 2010Symptoms and Side Effects of LRRK2 Mutation Carriers and Assessment of Factors Influencing LRRK2-related PD Expression
Objective/Rationale:
By incorporating our Spanish LRRK2 cohort with G2019S and R1441G mutations into the existing LRRK2 Cohort Consortium (L2CC) of people of Ashkenazi Jewish and North African Arab... -
MJFF Research Grant, 2010Development of Selective LRRK2 Inhibitors
Objective/Rationale:
LRRK2 kinase has been implicated as a potential therapeutic target for the treatment of Parkinson’s disease. The goal of our project is to make experimental drugs to test whether... -
MJFF Research Grant, 2010Male transgenic rat Parkinson's disease model characterization
Promising Outcomes of Original Grant:
The original project focused on the creation and characterization of pre-clinical models that express mutations in the protein alpha-synuclein that are known to... -
MJFF Research Grant, 2009N-Acetylcysteine CSF Levels and Biomarkers in a Pre-clinical Model of PD
Objective/Rationale:
N-Acetylcysteine (NAC) is an orally absorbed compound that supports neuronal synthesis of glutathione, a key neuronal antioxidant. Our objective here is to establish the blood and... -
Rapid Response Innovation Awards, 2009Generation of Dorsal Motor Nucleus (DMN) Specific Pre-clinical Model of Alpha-Synuclein Overexpression to Study Etiology of Autonomic Dysfunction in PD
Promising Outcomes of Original Grant:
According to Braak Staging of PD Pathology, the dorsal motor nucleus (DMN) is one of the earliest brain nuclei that accumulate alpha-Synuclein (aSyn) pathology...
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Our funding programs support basic, translational and clinical research from academia and industry.