The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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LRRK2 Therapeutic and Safety Initiative, 2016Evaluation of LRRK2 Inhibition in a Pre-clinical Model of Parkinson's Disease
Study Rationale:
The most common genetic cause of Parkinson's disease (PD) is mutations in the LRRK2 gene. Variations in the LRRK2 gene are associated with non-genetic PD as well. New drugs are being...
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Improved Biomarkers and Clinical Outcome Measures, 2016Identification of Tear Biomarkers for Individuals with Parkinson's Disease
Study Rationale:
Prior to the appearance of classic movement abnormalities like tremor and slowness, those with Parkinson's suffer from non-motor symptoms, such as altered function of the... -
Research Grant, 2016Chemical Knockdown of LRRK2 by Small Molecule PROTACS
Study Rationale:
LRRK2 is a protein kinase that appears to be a key driver of some forms of Parkinson's disease (PD). Several potent, selective, brain-penetrant LRRK2 kinase inhibitors have been...
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Target Advancement Program, 2016Using LRRK2 Computer Simulations to Identify Therapeutic Targets for Parkinson's Disease
Study Rationale:
LRRK2 interacts with over 60 proteins and alters several molecular pathways, including autophagy (cell break down), mitochondria (powerhouses of the cell), neurites (cellular... -
Target Advancement Program, 2016Targeting the Cell's Energy System in Parkinson's Disease
Study Rationale:
Mitochondria, cellular power plants, malfunction in Parkinson's disease (PD) and with advanced age. Aging and PD cause changes in communication between mitochondria and the rest of... -
Target Advancement Program, 2016Role of Inflammation in Parkinson's Disease
Hypothesis:
We hypothesize that the inflammatory protein galectin-3 contributes to PD progression.Study Design:
We will use pre-clinical models that lack galectin-3 to evaluate inflammation, neuronal...
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Our funding programs support basic, translational and clinical research from academia and industry.