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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2014
    Chemical Modulator of Chaperone-mediated Autophagy in Parkinson's Disease

    Objective/Rationale:
    Brain cells depend on very efficient surveillance systems to identify defective components and break them apart to avoid accumulation and toxicity. We have found that in the brain...

  • Rapid Response Innovation Awards, 2014
    Impact of the Medical Food ErgoD2® on Alpha-synuclein and Iron Levels

    Objective/Rationale:             
    Although the causes of Parkinson’s disease (PD) are yet unknown, the overall health of the body likely plays a major role in disease initiation and progression...

  • Therapeutic Pipeline Program, 2014
    Evaluating the Safety, Tolerability and Efficacy of SYN120 in Parkinson’s Disease Dementia

    Study Rationale:
    Cognitive impairments — common in Parkinson’s disease — are associated with an imbalance in neurotransmitters (substances that allow nerve cells to communicate with one another) such...

  • Research Grant, 2014
    Efficacy and Safety of APL-130277 in People with Parkinson’s Disease who are Apomorphine Naïve

    Study Rationale:                   
    Apomorphine is a drug that is used to control “off” episodes in people with Parkinson’s disease. At present, the drug is given by injection under the skin and starts...

  • Therapeutic Pipeline Program, 2014
    Effects on Gait and Balance of Augmenting Cholinergic Function

    Study Rationale:                   
    Impairments of gait and balance are common and life-altering in patients with Parkinson’s disease (PD). These impairments are incompletely controlled with...

  • Research Grant, 2014
    Parkinson's Disease Biomarker Discovery and Verification Using Multiple Reaction Monitoring

    Study Rationale:
    Multiple candidate Parkinson’s disease (PD) biomarkers have been identified over the years, but none have been properly validated. Using a targeted mass spectrometry platform, a...

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